TO SAVE AND
RESTORE
"Perhaps no structure is so intimately and simultaneously connected to both the energy of youth and the decline of the old"
— (Sun et al.; 2020)
Mitochondria are the powerhouses of the cell. cellvie is employing Therapeutic Mitochondria Transplantation, a technique of augmentation and replacement to reinvigorate the cell energy metabolism when the mitochondria are failing. The first application will be in ischemia-reperfusion injury, the world's number 1 killer.
MITOCHONDRIA ARE INTIMATELY TIED TO THE ORIGIN OF COMPLEX LIFE
Mitochondria are membrane-bound cell organelles that generate most of the energy needed to power the cell's biochemical reactions. In a process referred to as symbiogenesis, mitochondria are said to have merged with a simple cellular organism, giving rise to complex life and its evolution. In this process, Mitochondria took over vital roles within the cell, including:
ISCHEMIA-REPERFUSION Injury
cellvie is targeting ischemia-reperfusion injury as its technology's first application. Ischemia-Reperfusion is a ubiquitous challenge, arising whenever blood flow is interrupted and subsequently re-introduced. Medical conditions giving rise to ischemia-reperfusion injury are heart attacks, stroke, long surgical procedures and organ transplantation.
The first indication will be in kidney transplantation. With 12 patients dying each day waiting for a kidney, the need is particularly dear. The aim is to reduce the incidence of delayed graft function, which arises in up to 50% of kidney recipients.
EMERGENCE OF A NEW TREATMENT MODALITY
With mitochondria a common denominator in health as well as in disease and aging, cellvie strives to bring about Therapeutic Mitochondria Transplantation as a novel category of medicines. The approach's ability to sustainably affect the cell-energy-metabolism opens new avenues to treat hitherto intractable human conditions.
Beyond ischemia-reperfusion injury, the team at cellvie is particularly interested in the technology's application to slow or reverse degenerative processes of aging linked to the mitochondria.
