LEVERAGING THE POWER OF EVOLUTION

At cellvie, we are pioneering Therapeutic Mitochondria Transplantation, a novel treatment approach aimed at the cellular energy metabolism. We are deriving medicines from cells, leveraging one of the cornerstones of evolution: mitochondria.

LEVERAGING THE POWER OF EVOLUTION LEVERAGING THE POWER OF EVOLUTION
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Mitochondrium TO SAVE AND<br> RESTORE

TO SAVE AND
RESTORE

„Perhaps no structure is so intimately and simultaneously connected to both the energy of youth and the decline of the old”

— (Sun et al.; 2020)

Mitochondria are the powerhouses of the cell. cellvie is employing Therapeutic Mitochondria Transplantation, a technique of augmentation and replacement to reinvigorate the cell energy metabolism when the mitochondria are failing. The first application will be in ischemia-reperfusion injury, the world's number 1 killer.

Mitochondrium Description

ISCHEMIA-REPERFUSION Injury

cellvie is targeting ischemia-reperfusion injury as its technology's first application. Ischemia-Reperfusion is a ubiquitous challenge, arising whenever blood flow is interrupted and subsequently re-introduced. Medical conditions giving rise to ischemia-reperfusion injury are heart attacks, stroke, long surgical procedures and organ transplantation.

The first indication will be in kidney transplantation. With 12 patients dying each day waiting for a kidney, the need is particularly dear. The aim is to reduce the incidence of delayed graft function, which arises in up to 50% of kidney recipients.

ISCHEMIA-REPERFUSION Injury
Mitochondrium
EMERGENCE OF A NEW TREATMENT MODALITY

EMERGENCE OF A NEW TREATMENT MODALITY

With mitochondria a common denominator in health as well as in disease and aging, cellvie strives to bring about Therapeutic Mitochondria Transplantation as a novel category of medicines. The approach's ability to sustainably affect the cell-energy-metabolism opens new avenues to treat hitherto intractable human conditions.

Beyond ischemia-reperfusion injury, the team at cellvie is particularly interested in the technology's application to slow or reverse degenerative processes of aging linked to the mitochondria.

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